Single- versus multiple-sample method to measure glomerular filtration rate

FIT to measure glomerular filtration rate ( GFR )

A single-injection method for measuring glomerular filtration rate.

A method for estimating glomerular filtration rate (GFR) has been developed that is based on an analysis of the total area under the plasma radioactivity-time curve after a single intravenous injection of [125I]iothalamate. Glomerular filtration rates obtained by this method (method A) and those obtained with two widely used single-injection techniques, the slope-intercept method (method B), a...

Estimation of glomerular filtration rate in infants and in children using a single-plasma sample method.

This work was undertaken to look for distribution volume-plasma clearance converting equations(s) that can be used to estimate glomerular filtration rate (GFR) in children. GFR calculated using the two-blood sample slope-intercept method was used for comparison. It was shown that the 2-hr distribution volume and the two-blood sample clearance were closely related. For all the age groups, the co...

Estimated glomerular filtration rate.

The recent article about estimated glomerular filtration rate (GFR) by Levey and colleagues (1) is remarkable. The authors suggest that the new equation may still have some bias and especially may have less precision in patients with GFRs greater than 60 mL/min per 1.73 m 2 . This is even more important if the GFR is greater than 90 mL/min per 1.73 m 2 . In the paper's Methods section, Levey an...

Effect of extracellular fluid volume on single-sample measurement of glomerular filtration rate.

UNLABELLED Objective. The objective of our study was to evaluate the effect of extracellular fluid volume (ECV) on the accuracy of measurement of glomerular filtration rate from a single sample (GFR1). METHODS Multi-sample GFR (GFR6) and ECV (per 1.73 m(2)) were measured with both Cr-51-EDTA and iohexol, injected into opposite arms (110 studies in 80 subjects). Six plasma samples were obtaine...